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        Nc2Eye

           A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of diabetic retinopathy (DR)
ncRNA name MCP-1 siRNA
ncRNA Category siRNA
Disease name diabetic retinopathy (DR)
Species Rattus norvegicus
Tissues/Cell_line retinal neuronal cells
Methods immunohistochemistry, RT-PCR, Western blot, MTT assay, siRNA transfection, transwell assay, immunofluorescence, Chemotaxis assay, ELISA
Expression pattern associated
Functional description Retinal neurons that were pre-exposed to AGEs and an MCP-1 antibody or MCP-1 knockdown displayed greatly reduced microglial migration and TNF-α secretion.
PubMed ID 23010641
Year 2012
Title Upregulation of retinal neuronal MCP-1 in the rodent model of diabetic retinopathy and its function in vitro.
Drug-related ncRNA NO

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